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Lessons in Working Towards Global Eradication of Peste des Petits Ruminants (PPR) - Shared screen with speaker view
Charles BODJO
24:54
Just to inform all participant AU-PANVAC will conduct a study next year to determine the profile of all PPR Thermo-tolerant Vaccines. We encourage all vaccines Labs to participate to the trial.
MuhammadImam Afzal
25:48
This is Dr. M. Afzal from FAO-Pakistan
MuhammadImam Afzal
27:53
How soon are we starting?
Njeumi Felix
29:36
We will be starting at 1:15 GMT I think.
Meera Chandra
29:48
Hi everyone, we will begin at 8:30am EST
Charles BODJO
32:02
Just to inform all participants that AU-PANVAC will conduct a study next year to determine the profile of all thermo-tolerant PPR vaccines. We encourage all vaccine laboratories to participate in the trial and to send their vaccine to the following address:African Union CommissionAttention to: Pan African Veterinary Vaccine Centre(AU-PANVAC)P.O. Box 1746 Debre-Zeit, EthiopiaTel: +251 114338001; Fax: +251 114338844E-mail: aupanvac@africa-union.org
Charles BODJO
34:12
I am from African Union Commission- Pan African Veterinary Vaccine Centre (AU-PANVAC)
Saskia Hendrickx
34:50
Thank you Dr. Bodjo for the information
Michel Dione
35:54
Hello From Dakar Senegal
Dr. Amol Gulhane
39:49
Hello everyone, This is Dr. Amol from India
Camilla Benfield
48:48
Hello everyone. Camilla Benfield, Consultant for FAO GEP
Cate Flanley
49:23
Hello! Cate Flanley from USAID
Andrew Bisson
50:04
Greetings all, Andrew Bisson, Livestock Advisor, RFS/ USAID
Dr. Ashish Deshpande
50:15
Greetings from Dr. Ashish From Hester India
Paula Menzies
51:03
Good morning Dr. Paula Menzies from University of Guelph, Canada
DR. SURAJIT BAKSI
54:29
Greetings from Dr. Baksi From Hester India
Catherine Herzog
54:54
Good morning, Dr. Catherine Herzog, Penn State University, USA.
kaouther oukaili
56:41
Hello KAOUTHER OUKAILI from Tunisia FAO sub-regional office for north africa
Rajiv Gandhi
57:00
We commit to host the next meeting. Rajiv, Hester
Charles BODJO
57:05
AU-PANVAC will conduct a study next year to determine the profile of all thermo-tolerant PPR vaccines. We encourage all vaccine laboratories to participate into the trial and to send their vaccine to the following address:African Union Commission-Pan African Veterinary Vaccine Centre (AU-PANVAC)P.O. Box 1746 Debre-Zeit, EthiopiaTel: +251 114338001; Fax: +251 114338844E-mail: aupanvac@africa-union.org
Saskia Hendrickx
58:52
Thank you Dr. Bodjo for sharing this important information
Tyrell Kahan
01:00:09
Thanks Felix! Very good and informational overview!
Cate Flanley
01:00:47
Wonderful introduction, Felix!
Saskia Hendrickx
01:01:03
Project website: https://livestocklab.ifas.ufl.edu/projects/dr-adegbola-adesogan/
Charles BODJO
01:01:23
Good introduction of PPR vaccines issues
Saskia Hendrickx
01:02:45
PPR thermostable vaccine protocol: https://pubmed.ncbi.nlm.nih.gov/28566253/
Saskia Hendrickx
01:04:25
PNAVAC website: https://aupanvac.org/
Baba Soumare
01:04:39
This availability is very good news indeed
Camilla Benfield
01:05:27
@ Jeff: the data so far is tissue culture based - TCID50. Have field vaccination and challenge studies been done to show efficacy in vivo?
Barun Sharma
01:06:38
@ Jeff; what is the efficacy of the vaccine after reconstituion? How long could it be stored after reconstitution?
Saskia Hendrickx
01:06:53
@Camila - we will address questions at the end of the webinar. I'm capturing all questions
Charles BODJO
01:07:03
3 Processes developed to improve PPR vaccine stability1- Xerovac Technique (PANVAC): Worrwall E.E, Litamoi J.K., Seck B.M. & Ayelet G. (2001). Vaccine,19:834–8392- IBET Technique (Portugal) :Silva A.C., Carrondo M.J. & Alves P.M. (2011). – Strategies for improved stability of peste des petits ruminants vaccine.Vaccine, 29:4983-4991.3- Mariner JC, Gachanja J, Tindih SH, Toye P. A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia. Vaccine. 2017 Jun 27;35(30):3773-3779.
Saskia Hendrickx
01:07:33
Useful links for participatory epidemiology:Research articles on Participatory Epidemiology:Jost, C.C., Mariner, J.C., Roeder, P.L., Sawitri, E. and Macgregor-Skinner, G.J. 2007. Participatory epidemiology in disease surveillance and research. Scientific and Technical Review 26(3): 537-549.Allepuz A, de Balogh K, Aguanno R, Heilmann M, Beltran-Alcrudo D (2017) Review of Participatory Epidemiology Practices in Animal Health (1980-2015) and Future Practice Directions. PLoS ONE 12(1): e0169198. https://doi.org/10.1371/journal.pone.0169198Manual on Participatory Disease Surveillance:Ameri, A.A., Hendrickx, S., Jones, B., Mariner, J., Mehta, P. and Pissang, C. 2009. Introduction to participatory epidemiology and its application to highly pathogenic avian influenza participatory disease surveillance: A manual for participatory disease surveillance practitioners. Nairobi, Kenya: ILRI. https://hdl.handle.net/10568/367
Saskia Hendrickx
01:08:05
Check the publication on these findings: Nkamwesiga, J., Coffin-Schmitt, J., Ochwo, S., Mwiine, F.N., Palopoli, A, Ndekezi, C., Isingoma, E., Nantima, N., Nsamba, P., Adiba, R., Hendrickx, S. and Mariner, J.C. 2019. Identification of Peste des Petits Ruminants Transmission Hotspots in the Karamoja Subregion of Uganda for Targeting of Eradication Interventions. Front. Vet. Sci. 6:221. DOI: 10.3389/fvets.2019.00221
Saskia Hendrickx
01:09:40
Acosta, D., Hendrickx, S., McKune, S. 2019. The livestock vaccine supply chain: Why it matters and how it can help eradicate peste des petits Ruminants, based on findings in Karamoja, Uganda. Vaccine. 37(43):6285-6290. DOI:10.1016/j.vaccine.2019.09.011
Charles BODJO
01:11:04
With the next year project we are going to test the TT vaccine up to 30 days
Charles BODJO
01:11:15
at AU-PANVAC
Charles BODJO
01:12:01
The study will allow to determine the profile of each PPR TT Vaccine
Baba Soumare
01:12:40
Congratulations Jeff. The attention given to the delivery aspects of the vaccine is commendale as it is key success
Saskia Hendrickx
01:12:51
Project website: https://www.ilri.org/research/projects/feed-future-mali-livestock-technology-scaling-program
Charles BODJO
01:15:27
A preliminary study conducted at AU-PANVAC set out 10 days for 25oC and 5 days for 40oC as minimum requirement for TT PPR vaccine.
Jeffrey Mariner
01:17:35
Once any of these vaccine candidates is rehydrated, the shelf life is the same as for the normal vaccines. The recommendation is that they should be rehydrated with saline and used with 2 hours
Saskia Hendrickx
01:18:26
“ILRI” PPR thermostable vaccine protocol: https://pubmed.ncbi.nlm.nih.gov/28566253/ Same protocol as what shared earlier by Jeff Mariner
Saskia Hendrickx
01:18:57
Wane A, Dione M, Wieland B, Rich KM, Yena AS, Fall A. Willingness to Vaccinate (WTV) and Willingness to Pay (WTP) for Vaccination Against Peste des Petits Ruminants (PPR) in Mali. Front Vet Sci. 2020;6:488. Published 2020 Jan 15. oi: 10.3389/fvets.2019.00488
Saskia Hendrickx
01:19:50
related publication: Dione MM, Traoré I, Kassambara H, et al. Integrated Approach to Facilitate Stakeholder Participation in the Control of Endemic Diseases of Livestock: The Case of Peste Des Petits Ruminants in Mali. Front Vet Sci. 2019;6:392. Published 2019 Nov 19. ttps://doi.org/10.3389/fvets.2019.00392
Saskia Hendrickx
01:20:19
Dione, et al. 2017. Feed the Future Mali: Scaling up technological and institutional livestock innovations. MLTSP Brief 1. Nairobi, Kenya: ILRI. https://cgspace.cgiar.org/handle/10568/89014Sadio et al. 2018. Feed the Future Mali: Factors limiting participation of farmers in livestock vaccination programs in Mali. MLTS Brief 2. Nairobi, Kenya: ILRI. https://cgspace.cgiar.org/handle/10568/98884
Charles BODJO
01:20:22
3 Processes developed to improve PPR vaccine stability1- Xerovac Technique (PANVAC): Worrwall E.E, Litamoi J.K., Seck B.M. & Ayelet G. (2001). Vaccine,19:834–8392- IBET Technique (Portugal) :Silva A.C., Carrondo M.J. & Alves P.M. (2011). – Strategies for improved stability of peste des petits ruminants vaccine.Vaccine, 29:4983-4991.3- Mariner JC, Gachanja J, Tindih SH, Toye P. A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia. Vaccine. 2017 Jun 27;35(30):3773-3779.
Saskia Hendrickx
01:22:09
Project website: https://www.partneringforinnovation.org/hester-biosciences-nepal
Baba Soumare
01:22:30
Congrat Michel! Great expérience and learning to disséminate
Bonto Faburay
01:22:38
Well done Michel! Great work.
THOMAS DULU
01:23:28
Thanks Dr Dione for the clarity of your presentation
Njeumi Felix
01:23:46
Well done Michel. We will use these information
Renata Serra
01:25:33
Great presentation Michel. We should partner in Mali (where I worked for many years) for identifying and testing gender-sensitive strategies that improve uptake of PPR vaccines. Good to see you again (virtually).
Tyrell Kahan
01:25:43
How are challenges to PPR control the same and/or different by the 3 regions that each program worked in?
Saskia Hendrickx
01:26:54
Agrilinks blogpost on this project: https://www.agrilinks.org/post/out-cold-private-sector-tailors-new-animal-vaccine-build-resilience-among-nepals-rural-herders
Saskia Hendrickx
01:27:25
Partnering for Innovation’s lessons learned from commercializing research products: https://www.partneringforinnovation.org/research-to-commercialization
nargiza ludgate
01:28:28
Can you elaborate on how you envision to generate fee-for-vaccination strategy for TPPR in Nepal while PPR production within Nepal is heavily subsidized and offered to smallholders free of cost?
Surendra Karki
01:29:01
@Laura: Good to see this progress. My question: The planned distribution of 400,000 dosage of vaccine is free for farmers or is on a cost sharing basis? In which areas are these vaccines going (who will select these areas)?
Tyrell Kahan
01:30:50
Going forward, what would be some of the most important considerations for the development of public-private partnerships focused on eradication of PPR? What are the optimal roles of public partners vs private sector partners in these institutional arrangements?
Saskia Hendrickx
01:30:57
Partnering for Innovation’s lessons learned from commercializing research products: https://www.partneringforinnovation.org/research-to-commercialization
Dr.sharmila Chapagain
01:31:01
Its good to know . I want o know the quality test of vaccine targated animals /research
Cate Flanley
01:32:10
Thank you Jeff, Michel, and Laura for the informative presentations!
Paula Menzies
01:32:13
WRT the thermotolerant vaccines, is there work on multivalent vaccines (e.g. S&G pox)
Tyrell Kahan
01:32:31
Any need for financing or investment? What are those opportunities?
Tor Edwards
01:32:43
I'm in USAID/Uganda, and we're interested in contacting the teams that are working here for further info.
Kathryn Stahlberg
01:33:13
I was very interested in the participatory risk mapping work. Were there any particular challenges to implementing?
MuhammadImam Afzal
01:33:25
Thermostable vaccine use can facilitate eradication
olivier kwiatek CIRAD France
01:34:27
Is this vaccine thermotolerant because it is a modified Nigeria 75/1 strain or due to the diluent or lyophilastion technique used? More generally, what is the lyophilization substrate used by vaccine producers (Weybridge, milk, other) and have thermostability studies been carried out on these substrate?
Veronica O'Connor
01:34:42
Hello all. for your information, a recent Agrilinks article on Feed the Future Partnering for Innovation’s partnership with Hester:
Charles BODJO
01:34:52
What was the explanation of the difference between the XEROVAC and ILRI technique used to produce PPR TT vaccine in LCV Mali?
Veronica O'Connor
01:34:54
https://www.agrilinks.org/post/commercially-available-first-time-thermostable-peste-des-petits-ruminants-vaccine
Paula Menzies
01:35:10
Are any projects examining ways of identifying vaccinated animals and looking at generation turnover in flocks?
Zoe Campbell
01:35:32
Is anyone else thinking about gender-sensitive vaccination strategies? Would like to be in touch! z.campbell@cgiar.org
Saskia Hendrickx
01:37:06
@Zoe Campbell not as part of these projects but UF is implementing a project looking into this. please contact nrakhimova@ufic.ufl.edu
Njeumi Felix
01:37:12
@Zoe yes we can work jointly about gender-sensitive vaccination strategies. PPR-Secretariat@fao.org or felix.njeumi@fao.org
Zoe Campbell
01:37:36
Great, I'll reach out. :)
MuhammadImam Afzal
01:37:44
70 cents is very high cost for smallholders
Tyrell Kahan
01:38:03
Any need to booster this vaccine? If so, how will we ensure the booster is received?
Njeumi Felix
01:38:32
What will be the process for other laboratory to have access to the technology to also produce the thermotolerant vaccines?
Saskia Hendrickx
01:39:05
Manual on Participatory Disease Surveillance:Ameri, A.A., Hendrickx, S., Jones, B., Mariner, J., Mehta, P. and Pissang, C. 2009. Introduction to participatory epidemiology and its application to highly pathogenic avian influenza participatory disease surveillance: A manual for participatory disease surveillance practitioners. Nairobi, Kenya: ILRI. https://hdl.handle.net/10568/367
Saskia Hendrickx
01:39:20
the manual was developed for HPAI but can be adapted for PPR
nargiza ludgate
01:40:09
Dear Raj Gera, we (University of Florida) will be interested to re-connect to discuss collaboration in reaching underserved areas in Nepal. We recently concluded the intersectional assessment of the PPR vaccine value chain in Nepal (lower nodes of vaccine delivery services) and will be happy to share our findings with your group. I will email you soon to set up a meeting. Thanks for presentation
Saskia Hendrickx
01:40:20
7 cent per dose
Michel Dione
01:42:18
@Kathryn Under the EcoPPR project we are aslo implementing Partcicpatory risk mapping in West Africa...so happy to https://cgspace.cgiar.org/bitstream/handle/10568/109076/eco_ppr_en.pdf?sequence=5&isAllowed=y
Leon Gwaka
01:43:24
are the teams leveraging mobile technologies to speed up logistics, create awareness and share information?
Mahesh Chander
01:43:36
One of my PhD students recently completed phd thesis on participatory approaches in ppr vaccination. He underwent two months training on Participatory methods concerning ppr at ILRI, Nairobi.
Surendra Karki
01:43:41
Thank you.
Bryony Jones
01:43:55
We developed a manual on PPR surveillance for Ethiopia which includes PDS for PPR - if anyone wants a copy of that manual drop me an email bajones@rvc.ac.uk
Bryony Jones
01:45:27
And we have adapted this PPR PDS for the ILRI ECoPPR project - https://www.ilri.org/publications/epidemiology-and-control-peste-des-petits-ruminants-eco-ppr-field-researcher-manual
Charles BODJO
01:46:05
PANVAC has worked to transfer vaccine production technology in African labs
Charles BODJO
01:46:38
We did for XEROVAC
Saskia Hendrickx
01:47:30
Please also see information that Dr. Hodjo from PANVAC shared earlier:
Saskia Hendrickx
01:47:59
3 Processes developed to improve PPR vaccine stability1- Xerovac Technique (PANVAC): Worrwall E.E, Litamoi J.K., Seck B.M. & Ayelet G. (2001). Vaccine,19:834–8392- IBET Technique (Portugal) :Silva A.C., Carrondo M.J. & Alves P.M. (2011). – Strategies for improved stability of peste des petits ruminants vaccine.Vaccine, 29:4983-4991.3- Mariner JC, Gachanja J, Tindih SH, Toye P. A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia. Vaccine. 2017 Jun 27;35(30):3773-3779.
Andrew Bisson
01:48:20
Thanks to all presenters, wonderful discussion. May I suggest the formula for success is good transboundary coordination + an effective vaccine + effective delivery systems. USAID remains committed to supporting the PPR eradication campaign. May I suggest a future webinar sharing lessons learned on effective delivery systems, including willingness to pay for vaccine and PPP approaches would be a useful next step as USAID and other projects obtain results
Dr. Amol Gulhane
01:50:08
Thanks to all presenters and organizers for this wonderful webinar depicting current update regarding PPR eradication program.
DR. SURAJIT BAKSI
01:50:23
It is excellent discussion
Dr. Ashish Deshpande
01:50:26
Thanks all and organisers for the session
Cate Flanley
01:50:33
Thank you!
Tyrell Kahan
01:50:34
Great job everyone!
Gijs van 't Klooster
01:50:39
bye thank you
DR. SURAJIT BAKSI
01:50:49
Thank you all
Dr. Ashish Deshpande
01:51:09
informative and excellent bye
Vivian O'Donnell
01:51:13
Thank you so much to all the presenters and organizers for great presentations!!
Thomas Randolph
01:51:20
The EcoPPR project mentioned by Michel is looking at the various epidemiological parameters mentioned earlier e.g. implications of generation turn-over
Renata Serra
01:51:26
Great job Saskia for sharing so many resources! Thanks to all, this was really great.
Andrew Bisson
01:51:27
An all round excellent effort - congrats everyone
Vivian O'Donnell
01:51:30
Thanks for all the links provided as well
Catherine Herzog
01:51:47
Thank you, wonderful and informative presentations! Exciting!
Catherine Herzog
01:51:56
And for the links
Mahesh Chander
01:52:27
thanks
Michel Dione
01:52:34
https://www.ilri.org/news/epidemiology-and-control-peste-des-petits-ruminants-east-and-west-africa
Michel Dione
01:52:47
EcoPPR project https://www.ilri.org/news/epidemiology-and-control-peste-des-petits-ruminants-east-and-west-afric